Posted by Raw Revelations on Mar 17th 2025
About Our Betaine TMG (Trimethylglycine) Supplement
If your search for a supplement that might be able to boost liver function, and which was also highly anti-inflammatory and antioxidant, brought you to betaine or TMG (trimethylglycine) then you’re in luck. You’re in the right place - and here’s what you need to know.
First Off, What Is Trimethylglycine?
Before we can launch into some of the benefits of betaine or TMG, we need first to explain what it is and why that matters.
Trimethylglycine is a glycine group, an essential amino acid, with three methyl groups attached to it. Glycine itself is central to the body’s production of glutathione, an important antioxidant and anti-inflammatory compound.
This compound is also known as betaine or betaine anhydrous, and though it is produced endogenously, it is also commonly found in foods like beets, spinach, wheat, and quinoa.
This compound is heavily involved in liver function, supports cellular reproduction, and helps the body regulate another amino acid, homocysteine, which is critical to supporting the production of proteins in the blood.
Though trimethylglycine (TMG) is found in many foods, occurs naturally, and can be made by the body, there are many potential benefits to supplementing endogenous production with a betaine (TMG) supplement.
What Are the Benefits of Our Betaine TMG?
Taking a betaine or TMG supplement may have a number of positive health effects over the long term.
Among these are that betaine may support overall, optimal health of the autonomic nervous system. This is because, as a potent antioxidant, betaine can help shield the cells of the nervous system against oxidative stress and damage.
For this reason (and despite the fact that the exact mechanism of action is not understood) betaine may be therapeutic for individuals suffering from diseases such as Alzheimer’s or Parkinson’s, schizophrenia, and other neurodegenerative diseases.
Betaine supplements may also show positive effects on individuals affected by alcoholic liver diseases and heart disease. In fact, its role in liver support is one of its most important.
As a hepatoprotectant, betaine may also show promise in improving NAFLD (nonalcoholic fatty liver disease) as well as hepatic insulin resistance. Betaine has also been demonstrated to protect liver function, in cases of both acute and chronic injury, by counteracting oxidative stresses.
It also regulates mitochondrial function (an important mechanism for hepatoprotection) as well as offering antifibrotic properties. Serving as an antifibrotic may support overall liver health by preventing scarring and chronic damage. On top of that, betaine or TMG may also inhibit insulin resistance. The methyl groups of TMG may also support kidney function as well as liver function.
Betaine is associated with other interesting positive effects as well. For instance, it can both support homocysteine production and counteract high homocysteine levels (which can be deleterious or overall wellness). It may also support higher levels of SAMe in the blood.
If you’ve never heard of it, SAMe, or S-adenosil-methionine, is a co-substrate compound often used in the administration of antidepressants. It helps produce and regulate hormones and serves to support cell membrane function, among other effects, but its most pointed effects have to do with treatment of depression.
While more research may be necessary, another study indicated that, among those who took TMG and SAMe, depressive effects were mitigated more effectively than among those who only took SAMe. A TMG supplement may also effectively boost your energy levels.
Betaine may also be implicated in heart health. Some studies have shown that it may be able to help lower homocysteine levels, protecting the heart against heart disease. More research is needed, however.
Betaine supplements may also support overall athletic performance. Consistent betaine supplementation has been shown to improve strength, speed, and sustained sprinting ability.
Still Have Questions About the Effects of Betaine or TMG?
Still wondering if a betaine/TMG supplement is for you? On top of the benefits mentioned, TMG may also help with detoxification as well as stress response.
In addition, our TMG supplement is not synthetic, unlike most others on the market. Ours is derived from non-GMO sugar beets.
It’s also easy to use, and there are many ways to use it. Our simplest suggestion is to dissolve a half teaspoon to a teaspoon in water or juice and enjoy it that way, once to twice per day.
If you have any questions about trimethylglycine before you decide to buy, get in touch with us at hello@rawrevelations.com and we would be more than happy to help.